Use of Tranexamic Acid during Total Endoprosthetic Replacement of the Hip Joint
https://doi.org/10.15360/1813-9779-2010-5-62
Abstract
Objective: to evaluate the blood-saving activity, efficacy, and safety of tranexamic acid. Subjects and methods. Thirty-seven patients allocated into two groups were enrolled in the study of the efficacy of tranexamic acid as an agent in reducing blood loss during hip joint replacement. Group 2 patients were injected tranexamic acid, 10 mg/kg body weight, 20—30 minutes before and 3 hours after surgery in the same dosage. This resulted in a significant (48.5%) reduction in total blood loss (from 1089.6 to 560.8 ml) (p<0.05). No tranexamic acid-induced complications were found. The administration of tranexamic acid during total endoprosthetic replacement of the hip joint could reduce blood loss by 35 and 59.4% in the intraoperative and postoperative periods, respectively, and total blood loss by 48.4%. The use of tranexamic acid allows one to refuse transfusion of blood components during total endoprosthetic replacement of the hip joint. Key words: hip joint replacement, blood loss, tranexamic acid.
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Review
For citations:
Selivanov D.D., Sungurov V.A., Likhvantsev V.V., Konev D.Ye., Moiseikina L.A. Use of Tranexamic Acid during Total Endoprosthetic Replacement of the Hip Joint . General Reanimatology. 2010;6(5):62. (In Russ.) https://doi.org/10.15360/1813-9779-2010-5-62
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