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Общая реаниматология

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Роль оксида азота в повреждении нейронов при критических состояниях

https://doi.org/10.15360/1813-9779-2009-5-80

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Аннотация

Представленный литературный обзор включает в себя современные положения о роли оксида азота и его метаболизма в развитии энцефалопатий у больных в критическом состоянии. Описаны механизмы участия оксида азота в нейроток-сичности, индукции апоптоза нейронов, варианты участия оксида азота в развитии ишемии головного мозга, очаговом повреждении головного мозга при тяжелой черепно-мозговой травме. Дается краткий обзор экспериментально обоснованных методов терапии, направленных на коррекцию повреждения нейронов, опосредованных оксидом азота (модуляция синтеза оксида азота, антиоксиданты). Ключевые слова: ишемия головного мозга, травматические повреждения головного мозга, оксид азота, варианты синтазы оксида азота, нейротоксичность, апоптоз, пути коррекции.

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Для цитирования:


Киселева А., Чурляев Ю.А., Григорьев Е.В. Роль оксида азота в повреждении нейронов при критических состояниях . Общая реаниматология. 2009;5(5):80. https://doi.org/10.15360/1813-9779-2009-5-80

For citation:


Kiseleva A.V., Churlyaev Y.A., Grigoryev Y.V. Role of Nitric Oxide in Neuronal Damages in Critical Conditions . General Reanimatology. 2009;5(5):80. (In Russ.) https://doi.org/10.15360/1813-9779-2009-5-80

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ISSN 1813-9779 (Print)
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