The properties of ozonized perfluorane were first studied in the treatment of experimental generalized peritonitis. Experiments were conducted on albino noninbred rats. The model of acute peritonitis, proposed by S. S. Remennik, was used. After simulating peritonitis, the animals were intraperitoneally injected saline solution (Series 1), perfluorane (Series 2), ozonized saline solution (Series 3), ozonized perfluorane (Series 4). All the animals intraperitoneally given saline solution died on days 1—7 of the experiment. When ozonized perfluorane was used, all the animals survived. The therapeutic effect of ozonized perfluorane in acute peritonitis was due to the activation of phagocytes and to the antibacterial activity of ozone.

The paper deals with the clinical and experimental studies of the pathogenetic factors underlying the development of septic encephalopathy in the presence of the systemic inflammatory response syndrome. Particular emphasis is laid on carbohydrate metabolic disturbances in the brain as one of the most important factor for neurons. The experimental section presents the age-related features of cerebral carbohydrate metabolism in the development of sepsis.

The paper deals with the reduction in a risk for infectious and inflammatory complications after cesarean section under regional anesthesia in parturient females with moderate gestosis. It emphasizes the positive impact of addition of dexam-ethasone, pentoxifyilline, dalargin to complex therapy on the immune system.

The paper shows that the treatment of brain traumatic lesions is a topical problem. Moreover, the complications associated with the development of cerebral recompression play a particular role in the posttraumatic period. The purpose of the present study was to reveal the regularities of reorganization of cyto- and synaptoarchitectonics of different layers of the cerebral cortex in patients with cerebral recompression in the acute period of brain injury. Cerebral cortical biopsy specimens taken in 6 patients from the perifocal area (subdural hematoma and a contusion focus with intracerebral hematoma) were examined. The results were statistically processed, by using a package of the applied programs «StatSoft Statistica 6.0». Based on the findings, the authors suggest that it is necessary to make an early diagnosis and a complex intervention that promotes the improvement of the ultimate results of treatment.

The hemostatic system was studied in 36 miners (Group 1) who were in the critical condition after severe brain injury (SBI). Group 2 comprised 21 working miners. In both groups, the length of underground service was more than 10 years. The studies indicated that the miners working under underground conditions had moderate hemostatic changes manifesting as endothelial lesions, platelet dysfunction, and coagulatory and kallikrein-dependent fibrinolytic disorders. These impairments promoted the development of the disseminated intravascular coagulation syndrome in the miners with SBI-induced critical condition.

Twelve patients with acute myocardial infarction and 41 patients with postinfarct cardiosclerosis complicated by NYHA Functional Classes I—IV chronic heart failure (CHF) were examined. The structural and functional status of the left and right cardiac cavities was evaluated by echocardiography. Remodeling processes separately occurred in the left ventricle (LV) in the acute period of myocardial infarction. The structural and functional rearrangement of the right cardiac chambers in patients with CHD and CHF proceeds simultaneously with LV remodeling processes, starting from the earliest stages. In patients with CHF and rigid diastolic dysfunction with normal LV filling pressure and mean pulmonary and right atrial pressures, the observing dilatation of the right ventricle is one of the signs of its remodeling.

The lecture presents the materials of foreign studies on the mechanisms responsible for the formation of a systemic inflammatory response syndrome (SIRS). The hypotheses accounting for the occurrence of SIRS in emergencies are described. Adhesion molecules (AM) and endothelial dysfunction are apparent to be involved in the inflammatory process, no matter what the causes of SIRS are. The current classification of AM and adhesion cascades with altered blood flow is presented. There are two lines in the studies of AM. One line is to measure the concentration of AM in the plasma of patients with emergencies of various etiology. The other is to study the impact of antiadhesion therapy on the alleviation of the severity of terminal state and its outcome. The studies provide evidence for that an adhesive process is a peculiar prelude to a systemic inflammatory response.

The impact of the pattern of a pulse electrical field generated by a defibrillator discharge on the efficiency of membranous electroporation was studied in a model experiment on human erythrocytic suspension. The initial temperature and time parameters of the model were substantiated. The rate of cellular hemolysis under the action of two impulses was shown to be increased by 1.2—3.5 times as compared with that under the action of one impulse. Electroporation was more effective and its threshold was lower under the action of two heterodirectional pulses as compared with that under the action of two unidirectional ones. These dependencies are statistical.

The changes in the parameters of the transporting capacity of albumin, in some biochemical plasma parameters, and in the impact of low-energy laser irradiation on the studied parameters were examined in patients with severe mechanical injury in the early posttraumatic period. Thirty patients aged 17 to 70 years who had a health status of 78 to 98 scores by the APACHE-III scale were examined. The results indicated that as a consequence of prior hypoxia of mixed genesis and subsequent reperfusion and later on due to the development of endogenous intoxication, there were changes in the transporting capacity of albumin and in the de Ritis coefficient, a reduction in cholesterol concentrations, and increases in the levels of triglycerides and in the activity of gamma-glutamyl transpeptidase. Early quantum hemotherapy as a part of complex treatment makes it possible to prevent the progressive deterioration of the transporting capacity of plasma albumin, the critical reduction in the effective concentration of albumin, contributes to a more rapid recovery of the lowered levels of cholesterol and to a further increase in the activity of gamma-glutamyl transpeptidase, which is indicative of the recovered biosynthetic activity of the liver and its enhanced detoxifying activity.

The impact of hyperbaric oxygenation (HBO) on lipid peroxidation (LPO) and the antioxidative system (AOS) was studied in patients with isolated and combined brain injury, in those with female internal genital inflammatory diseases. HBO temporarily enhances endotoxicosis with its subsequent rapid decrease rate. The stimulation of LPO processes is directly related to the degree of underlying disorders caused by an injury or disease. The HBO therapy regimen should be individualized depending on the response of AOS.