Прогностическая значимость и терапевтический потенциал мозгового нейротрофическго фактора BDNF при повреждении головного мозга (обзор)

Нейротрофины — это белки, играющие важную роль в функционировании нервной системы, регулируя клеточную пролиферацию, дифференцировку, процессы выживания и гибели нейронов, участвуя в механизмах нейрональной пластичности. Мозговой нейротрофический фактор (Brain-Derived Neurotrophic Factor — BDNF) — один из наиболее охарактеризованных представителей семейства нейротрофинов, которому в последние годы уделяется пристальное внимание. Его считают одним из ключевых медиаторов выживания и восстановления нейронов, а снижение содержания BDNF является общим механизмом, лежащим в основе развития различных нейродегенеративных заболеваний. В обзоре рассмотрены изменения содержания BDNF при повреждении мозга, вызванном ишемией и травмой, перспективы его использования в клинике в качестве маркера нарушения функций мозга, а также возможности его применения для лечения постишемических энцефалопатий.

BDNF, нейротрофины, головной мозг, ишемия, черепно-мозговая травма (ЧМТ), нейропротекция

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