Прогностическая значимость и терапевтический потенциал мозгового нейротрофическго фактора BDNF при повреждении головного мозга (обзор)
Аннотация
Нейротрофины — это белки, играющие важную роль в функционировании нервной системы, регулируя клеточную пролиферацию, дифференцировку, процессы выживания и гибели нейронов, участвуя в механизмах нейрональной пластичности. Мозговой нейротрофический фактор (Brain-Derived Neurotrophic Factor — BDNF) — один из наиболее охарактеризованных представителей семейства нейротрофинов, которому в последние годы уделяется пристальное внимание. Его считают одним из ключевых медиаторов выживания и восстановления нейронов, а снижение содержания BDNF является общим механизмом, лежащим в основе развития различных нейродегенеративных заболеваний. В обзоре рассмотрены изменения содержания BDNF при повреждении мозга, вызванном ишемией и травмой, перспективы его использования в клинике в качестве маркера нарушения функций мозга, а также возможности его применения для лечения постишемических энцефалопатий.
Ключевые слова
Об авторах
И. В. Острова
НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР
Россия
Россия
Н. В. Голубева
НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР
Россия
Россия
А. Н. Кузовлев
НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР
Россия
Россия
А. М. Голубев
НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР;
Российский университет дружбы народов
Россия
Россия
Список литературы
1. Huang L., Applegate P.V., Gatling J.W., Mangus D.B., Zhang J., Applegate R.L.2nd. A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (part II-comprehensive protection). Med. Gas. Res. 2014; 4: 10. DOI: 10.1186/2045-9912-4-10. PMID: 25671079
2. Failla M.D., Conley Y.P., Wagner A.K. Brain-derived neurotrophic factor (BDNF) in traumatic brain injury-related mortality: interrelationships between genetics and acute systemic and central nervous system BDNF profiles. Neurorehabil. Neural. Repair. 2016; 30 (1): 83–93. DOI: 10.1177/1545968315586465. PMID: 25979196
3. Lorente I.L. Biomarkers associated with the outcome of traumatic brain injury patients. Brain Sci. 2017; 7 (11): pii: E142. DOI: 10.3390/brainsci7110142. PMID: 29076989
4. Chen A.I., Xiong L.J., Tong Y.U., Mao M. The neuroprotective roles of BDNF in hypoxic ischemic brain injury. Biomed. Rep. 2013; 1 (2): 167— 176. DOI: 10.3892/br.2012.48. PMID: 24648914
5. Gray J.D., Milner T.A., McEwen B.S. Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors. Neuroscience. 2013; 239: 214-227. DOI: 10.1016/j.neuroscience.2012.08.034. PMID: 22922121
6. Kimura A., Namekata K., Guo X., Harada C., Harada T. Neuroprotection, growth factors and BDNF-TrkB signalling in retinal degeneration. Int. J. Mol. Sci. 2016; 17 (9): pii: E1584. DOI: 10.3390/ijms17091584. PMID: 27657046
7. Choi Y., Kang S.G., Kam K.Y. Changes in the BDNF-immunopositive cell population of neocortical layers I and II/III after focal cerebral ischemia in rats. Brain Res. 2015; 1605: 76-82. DOI: 10.1016/j.brainres. 2015.02.007. PMID: 25681548
8. Shih P.C., Yang Y.R., Wang R.Y. Effects of exercise intensity on spatial memory performance and hippocampal synaptic plasticity in transient brain ischemic rats. PLoS One. 2013; 8 (10): e78163. DOI: 10.1371/journal.pone.0078163. PMID: 24205142
9. Kim G., Kim E. The effects of antecedent exercise on motor function recovery and brain-derived neurotrophic factor expression after focal cerebral ischemia in rats. J. Phys. Ther. Sci. 2013; 25 (5): 553–556. DOI: 10.1589/jpts.25.553. PMID: 24259800
10. Иванов А.Д. Роль NGF и BDNF в регуляции деятельности зрелого мозга. Журн. высш. нервн. деятельности им. И.П.Павлова. 2014; 64
11. (2): 137–146. DOI: 10.7868/S0044467714020099. PMID: 25713864
12. Schäbitz W.R., Steigleder T., Cooper-Kuhn C.M., Schwab S., Sommer C., Schneider A., Kuhn H.G. Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis. Stroke. 2007; 38 (7): 2165-2172. DOI: 10.1161/STROKEAHA.106. 477331. PMID: 17510456
13. Vilar M., Mira H. Regulation of neurogenesis by neurotrophins during adulthood: expected and unexpected roles. Front. Neurosci. 2016; 10: 26. DOI: 10.3389/fnins.2016.00026. PMID: 26903794
14. Berretta A., Tzeng Y.C., Clarkson A.N. Post-stroke recovery: the role of activity-dependent release of brain-derived neurotrophic factor. Expert. Rev. Neurother. 2014; 14 (11): 1335-1344. DOI: 10.1586/14737175.2014. 969242. PMID: 25319267
15. Budni J., Bellettini-Santos T., Mina F., Garcez M.L., Zugno A.I. The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease. Aging Dis. 2015; 6 (5): 331-341. DOI: 10.14336/AD.2015.0825. PMID: 26425388
16. Larpthaveesarp A., Ferriero D.M., Gonzalez F.F. Growth factors for the treatment of ischemic brain injury (growth factor treatment). Brain Sci. 2015; 5 (2): 165-177. DOI: 10.3390/brainsci5020165. PMID: 25942688
17. Аляутдин Р.Н., Романов Б.К., Лепахин В.К., Халин И.В., Бунятян Н.Д., Меркулов В.А., Миронов А.Н. Рекомбинантный нейротрофический фактор головного мозга (brain derived nerve factor; BDNF): панацея для мозга? Биопрепараты. Профилактика, диагностика, лечение. 2014; 2: 22-30.
18. Cai J., Hua F., Yuan L., Tang W., Lu J., Yu Sh., Wang X., Hu Y. Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases. BioMed Res. Int. 2014; 2014: 601084. DOI: 10.1155/2014/ 601084. PMID: 24818146
19. Korley F.K., Diaz-Arrastia R., Wu A.H., Yue J.K., Manley G.T., Sair H.I., Van Eyk J., Everett A.D.; TRACK-TBI investigators, Okonkwo D.O., Valadka A.B., Gordon W.A., Maas A.I., Mukherjee P., Yuh E.L., Lingsma H.F., Puccio A.M., Schnyer D.M. Circulating brain-derived neurotrophic factor has diagnostic and prognostic value in traumatic brain injury. J. Neurotrauma. 2016; 33 (2): 215–225. DOI: 10.1089/neu.2015.3949. PMID: 26159676
20. D’Cruz B.J., Fertig K.C., Filiano A.J., Hicks S.D., DeFranco D.B., Callaway C.W. Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. J. Cereb. Blood Flow Metab. 2002; 22 (7): 843-851. DOI: 10.1097/00004647-200207000-00009. PMID: 12142569
21. Miyake K., Yamamoto W., Tadokoro M., Takagi N., Sasakawa K., Nitta A., Furukawa S., Takeo S. Alterations in hippocampal GAP-43, BDNF, and L1 following sustained cerebral ischemia. Brain Res. 2002; 935 (1-2): 24-31. DOI: 10.1016/S0006-8993(02)02420-4. PMID: 12062469
22. Uchida H., Yokoyama H., Kimoto H., Kato H., Araki T. Long-term changes in the ipsilateral substantia nigra after transient focal cerebral ischaemia in rats. Int. J. Exp. Pathol. 2010; 91 (3): 256-266. DOI: 10.1111/j.1365-2613.2010.00712.x. PMID: 20353427
23. Tsukahara T., Iihara K., Hashimoto N., Nishijima T., Taniguchi T. Increases in levels of brain-derived neurotrophic factor mRNA and its promoters after transient forebrain ischemia in the rat brain. Neurochem. Int. 1998; 33 (2): 201-207. DOI: 10.1016/S0197-0186(97)00112-5. PMID: 9761465
24. Béjot Y., Prigent-Tessier A., Cachia C., Giroud M., Mossiat C., Bertrand N., Garnier P., Marie C. Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats. Neurochem. Int. 2011; 58 (1): 102-111. DOI: 10.1016/j.neuint.2010.10.019. PMID: 21074587
25. Lee T.H., Yang J.T., Ko Y.S., Kato H., Itoyama Y., Kogure K. Influence of ischemic preconditioning on levels of nerve growth factor, brain-derived neurotrophic factor and their high-affinity receptors in hippocampus following forebrain ischemia. Brain Res. 2008; 1187: 1-11. DOI: 10.1016/j.brainres.2007.09.078. PMID: 18036511
26. Ставчанский В.В., Творогова Т.В., Боцина А.Ю., Скворцова В.И., Лимборская С.А., Мясоедов Н.Ф., Дергунова Л.В. Семакс и его С-концевой фрагмент PGP влияют на экспрессию генов нейротрофинов и их рецепторов в условиях неполной глобальной ишемии мозга крыс. Молекулярная биология. 2011; 45 (6): 1026-1035. PMID: 22295573
27. Mokhtari T., Akbari M., Malek F., Kashani I.R., Rastegar T., Noorbakhsh F., Ghazi-Khansari M., Attari F., Hassanzadeh G. Improvement of memory and learning by intracerebroventricular microinjection of T3 in rat model of ischemic brain stroke mediated by upregulation of BDNF and GDNF in CA1 hippocampal region. Daru. 2017; 25 (1): 4. DOI: 10.1186/s40199-017-0169-x. PMID: 28202057
28. Park J.H., Lee T.K., Yan B.C., Shin B.N., Ahn J.H., Kim I.H., Cho J.H., Lee J.C., Hwang I.K., Kim J.D., Hong S., Lee Y.J., Won M.H., Kang I.J. Pretreated Glehnia littoralis extract prevents neuronal death following transient global cerebral ischemia through increases of superoxide dismutase 1 and brain-derived neurotrophic factor expressions in the gerbil hippocampal Cornu Ammonis 1 area. Chin. Med. J. (Engl.). 2017; 130 (15): 1796-1803. DOI: 0.4103/0366-6999.211554. PMID: 28748852
29. Shu X., Zhang Y., Xu H., Kang K., Cai D. Brain-derived neurotrophic factor inhibits glucose intolerance after cerebral ischemia. Neural. Regen. Res. 2013; 8 (25): 2370-2378. DOI: 10.3969/j.issn.1673-5374.2013.25.008. PMID: 25206547
30. Кулага Е.А., Гаврилова С.А., Буравков С.В., Кошелев В.Б. Динамика экспрессии мозгового нейротрофического фактора (BDNF) в коре головного мозга крыс и влияние препарата «Семакс» на его продукцию при моделировании ишемического инсульта. Регионарное кровообращение и микроциркуляция. 2013; 12 (3): 39-46.
31. Ando T., Takagi N., Takagi K., Kago T., Takeo S. Effects of nefiracetam on the levels of brain-derived neurotrophic factor and synapsin I mRNA and protein in the hippocampus of microsphere-embolized rats. Eur. J. Pharmacol. 2005; 507 (1–3): 49-56. DOI: 10.1016/j.ejphar.2004.11.033. PMID: 15659294
32. Аврущенко М.Ш., Острова И.В. Постреанимационные изменения экспрессии мозгового нейротрофического фактора (BDNF): взаимосвязь с процессом гибели нейронов. Общая реаниматология. 2017; 13 (4): 6-21. DOI: 10.15360/1813-9779-2017-4-6-21
33. Yan B.C., Park J.H., Kim S.K., Choi J.H., Lee C.H., Yoo K.Y., Kwon Y.G., Kim Y.M., Kim J.D., Won M.H. Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia. Cell Mol. Neurobiol. 2012; 32 (8): 1231-1242. DOI: 10.1007/s10571-012-9848-9. PMID: 22552890
34. Géral C., Angelova А., Lesieur S. From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF). Pharmaceutics. 2013; 5 (1): 127-167. DOI: 10.3390/pharmaceutics5010127. PMID: 24300402
35. Liu Z., Ma D., Feng G., Ma Y., Hu H. Recombinant AAV-mediated expression of human BDNF protects neurons against cell apoptosis in Abeta-induced neuronal damage model. J. Huazhong Univ. Sci. Technolog. Med. Sci. 2007; 27 (3): 233-236. DOI: 10.1007/s11596-007-0304-x. PMID: 17641830
36. Takeshima Y., Nakamura M., Miyake H., Tamaki R., Inui T., Horiuchi K., Wajima D., Nakase H. Neuroprotection with intraventricular brain-derived neurotrophic factor in rat venous occlusion model. Neurosurgery. 2011; 68 (5): 1334–1341. DOI: 10.1227/NEU.0b013e31820c048e. PMID: 21307800
37. Yang J.L., Lin Y.T., Chuang P.C., Bohr V.A., Mattson M.P. BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease. Neuromolecular Med. 2014; 16 (1): 161-174. DOI: 10.1007/s12017-013-8270-x. PMID: 24114393
38. Lu B. BDNF and activity-dependent synaptic modulation. Learn Mem. 2003; 10 (2): 86–98. DOI: 10.1101/lm.54603. PMID: 12663747
39. Zhou L., Lin Q., Wang P., Yao L., Leong K., Tan Zh., Huang Z. Enhanced neuroprotective efficacy of bone marrow mesenchymal stem cells co-overexpressing BDNF and VEGF in a rat model of cardiac arrest-induced global cerebral ischemia. Cell Death Dis. 2017; 8 (5): e2774. DOI: 10.1038/cddis.2017.184. PMID: 28492549
40. Ritter C., Miranda A.S., Giombelli V.R., Tomasi C.D., Comim C.M., Teixeira A.L., Quevedo J., Dal-Pizzol F. Brain-derived neurotrophic factor plasma levels are associated with mortality in critically ill patients even in the absence of brain injury. Crit. Care. 2012; 16 (6): R234. DOI: 10.1186/cc11902. PMID: 23245494
41. Голосная Г.С., Петрухин А.С., Терентьев А.А., Дуленков А.Б. Hейротрофический фактор головного мозга (BDNF) в ранней диагностике внутрижелудочковых кровоизлияний и перивентрикулярной лейкомаляции у новорожденных детей. Вопр. соврем. педиатрии. 2005; 4 (3): 13—18.
42. Живолупов С.А., Самарцев И.Н., Марченко А.А., Пуляткина О.В. Прогностическое значение содержания в крови нейротрофического фактора мозга (BDNF) при терапии некоторых функциональных и органических заболеваний нервной системы с применением адаптола. Журн. неврол. психиат. им. С.С. Корсакова. 2012; 112 (4): 37-41. PMID: 22810739
43. Каракулова Ю.В., Селянина Н.В. Мониторирование нейротрофических факторов и когнитивных функций у пациентов с черепно-мозговой травмой. Журн. неврол. психиат. им. С.С.Корсакова. 2017; 117 (10): 34-37. DOI: 10.17116/jnevro201711710134-37. PMID: 29171486
44. Селянина Н.В., Каракулова Ю.В. Влияние мозгового нейротрофического фактора на реабилитационный потенциал после черепно-мозговой травмы. Мед. альманах. 2017; 5: 76-79.
45. Pikula A., Beiser A.S., Chen T.C., Preis S.R., Vorgias D., DeCarli C., Au R., Kelly-Hayes M., Kase C.S., Wolf P.A., Vasan R.S., Seshadri S. Serum brainderived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study. Stroke. 2013; 44 (10): 2768-2775. DOI: 10.1161/STROKEAHA. 113.001447. PMID: 23929745
46. Xu H.B., Xu Y.H., He Y., Xue F., Wei J., Zhang H., Wu J. Decreased serum brain-derived neurotrophic factor may indicate the development of poststroke depression in patients with acute ischemic stroke: a meta-analysis. J. Stroke Cerebrovasc. Dis. 2018; 27 (3): 709-715. DOI: 10.1016/j.jstrokecerebrovasdis.2017.10.003. PMID: 29128330
47. Stanne T.M., Åberg N.D., Nilsson S., Jood K., Blomstrand C., Andreasson U., Blennow K., Zetterberg H., Isgaard J., Svensson J., Jern C. Low circulating acute brain-derived neurotrophic factor levels are associated with poor long-term functional outcome after ischemic stroke. Stroke. 2016; 47 (7): 1943-1945. DOI: 10.1161/STROKEAHA.115.012383. PMID: 27301948
48. Simon D., Nascimento R.I., Filho E.M., Bencke J., Regner A. Plasma brainderived neurotrophic factor levels after severe traumatic brain injury. Brain Inj. 2016; 30 (1): 23-28. DOI: 10.3109/02699052.2015.1077993. PMID: 26555864
49. Stefani M.A., Modkovski R., Hansel G., Zimmer E.R., Kopczynski A., Muller A.P., Strogulski N.R., Rodolphi M.S., Carteri R.K., Schmidt A.P., Oses J.P., Smith D.H., Portela L.V. Elevated glutamate and lactate predict brain death after severe head trauma. Ann. Clin. Transl. Neurol. 2017; 4 (6): 392–402. DOI: 10.1002/acn3.416. PMID: 28589166
50. Hughes C.G., Patel M.B., Brummel N.E., Thompson J.L., McNeil J.B., Pandharipande P.P., Jackson J.C., Chandrasekhar R., Ware L.B., Ely E.W., Girard T.D. Relationships between markers of neurologic and endothelial injury during critical illness and long-term cognitive impairment and disability. Intensive Care Med. 2018; 44 (3): 345-355. DOI: 10.1007/s00134-018-5120-1. PMID: 29523900
51. Kotlêga D., Peda B., Zembron ´-Łacny A., Goł¹b-Janowska M., Nowacki P. The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients. Neurol. Neurochir. Pol. 2017; 51 (3): 240-246. DOI: 10.1016/j.pjnns.2017.02.008. PMID: 28291539
52. Shen T., You Y., Joseph C., Mirzaei M., Klistorner A., Graham S.L., Gupta V. BDNF polymorphism: a review of its diagnostic and clinical relevance in neurodegenerative disorders. Aging Dis. 2018; 9 (3): 523-536. DOI: 10.14336/AD.2017.0717. PMID: 29896439
53. Hempstead B.L. Brain-derived neurotrophic factor: three ligands, many actions. Trans. Am. Clin. Climatol. Assoc. 2015; 126: 9-19. PMID: 26330656
54. Александрова Е.В., Юсупова М.М., Тенедиева В.Д., Сычёв А.А., Носиков В.В., Потапов А.А. Клиническое и прогностическое значение генетических маркеров при черепно-мозговой травме (часть III). Вопросы нейрохирургии им. Н.Н.Бурденко. 2014; 78 (3): 53-61. PMID: 25180329
55. Bao M.H., Zhu S.Z., Gao X.Z., Sun H.S., Feng Z.P. Meta-analysis on the association between brain-derived neurotrophic factor polymorphism rs6265 and ischemic stroke, poststroke depression. J. Stroke Cerebrovasc. Dis. 2018; 27 (6): 1599-1608. DOI: 10.1016/j.jstrokecerebrovasdis. 2018.01.010. PMID: 29449128
56. Kim J.M., Stewart R., Park M.S., Kang H.J., Kim S.W., Shin I.S., Kim H.R., Shin M.G., Cho K.H., Yoon J.S. Associations of BDNF genotype and promoter methylation with acute and long-term stroke outcomes in an East Asian cohort. PLoS One. 2012; 7 (12): e51280. DOI: 10.1371/journal. pone.0051280. PMID: 23240009
57. Шкловский В.М., Вильянов В.Б., Фукалов Ю.А., Ременник А.Ю., Скипетрова Л.А., Кобозев Г.Н., Орлов И.Ю., Петрушевский А.Г., Кудряшов А.В., Кокорева М.Е. Полиморфизм Val66Met BDNF у больных с высоким риском летальности в результате инсульта и тяжелой черепно-мозговой травмы. Молекулярная медицина. 2013; 2: 46-50.
58. Kiprianova I., Freiman T.M., Desiderato S., Schwab S., Galmbacher R., Gillardon F., Spranger M. Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat. J. Neurosci. Res. 1999; 56 (1): 21-27. DOI: 10.1002/(SICI)1097-4547(19990401)56:13.0.CO;2-Q. PMID: 10213471
59. Berger C., Schäbitz W.R., Wolf M., Mueller H., Sommer C., Schwab S. Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke. Exp. Neurol. 2004; 185 (2): 305-312. DOI: 10.1016/j.expneurol.2003.10.008. PMID: 14736512
60. Schäbitz W.R., Sommer C., Zoder W., Kiessling M., Schwaninger M., Schwab S. Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke. 2000; 31 (9): 2212-2217. DOI: 10.1161/01.STR.31.9. 2212. PMID: 10978054
61. Ferrer I., Krupinski J., Goutan E., Martí E., Ambrosio S., Arenas E. Brainderived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat. Acta Neuropathol. 2001; 101 (3): 229-238. PMID: 11307622
62. Jiang Y., Wei N., Lu T., Zhu J., Xu G., Liu X. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience. 2011; 172: 398-405. DOI: 10.1016/j.neuroscience.2010.10.054. PMID: 21034794
63. Сахарнова Т.А., Ведунова М.В., Митрошина Е.В., Мухина И.В. Антигипоксическое и нейропротекторное действие нейротрофических факторов BDNF и GDNF в условиях острой гипобарической гипоксии in vivo. Биомед. радиоэлектроника. 2014; 4: 71-72.
64. Massa S.M., Yang T., Xie Y., Shi J., Bilgen M., Joyce J.N., Nehama D., Rajadas J., Longo F.M. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J. Clin. Invest. 2010; 120 (5): 1774–1785. DOI: 10.1172/JCI41356. PMID: 20407211
65. Kazim S.F., Iqbal K. Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer’s disease. Mol. Neurodegener. 2016; 11 (1): 50. DOI: 10.1186/s13024-016-0119-y. PMID: 27400746
66. Khalin I., Alyautdin R., Kocherga G., Bakar M.A. Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness. Int. J. Nanomedicine. 2015; 10: 3245-3267. DOI: 10.2147/IJN. S77480. PMID: 25995632
67. Povarnina P., Gudasheva T.A., Seredenin S.B. Dimeric dipeptide mimetics of NGF and BDNF are promising agents for post-stroke therapy. JBiSE. 2018; 11 (5): 100-107. DOI: 10.4236/jbise.2018.115009
68. Gudasheva T.A., Povarnina P., Logvinov I.O., Antipova T.A., Seredenin S.B. Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats. Drug Des. Devel. Ther. 2016; 10: 3545-3553. DOI: 10.2147/DDDT.S118768. PMID: 27843294
69. Han J., Pollak J., Yang T., Siddiqui M.R., Doyle K.P., Taravosh-Lahn K., Cekanaviciute E., Han A., Goodman J.Z., Jones B., Jing D., Massa S.M., Longo F.M., Buckwalter M.S. Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxicischemic stroke. Stroke. 2012; 43 (7): 1918-1924. DOI: 10.1161/STROKEAHA.111.641878. PMID: 22535263
70. Habtemariam S. The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs. Neural. Regen. Res. 2018; 13 (6): 983–984. DOI: 10.4103/1673-5374.233438. PMID: 29926822
71. Romeika J., Wurzelmann M., Sun D. TrkB receptor agonist 7,8-dihydroxyflavone and its therapeutic potential for traumatic brain injury. In: Heidenreich K. (red.). New therapeutics for traumatic brain injury: prevention of secondary brain damage and enhancement of repair and regeneration. 2017; 225-234. DOI: 10.1016/B978-0-12-802686-1.00014-6
72. Uluc K., Kendigelen P., Fidan E., Zhang L., Chanana V., Kintner D., Akture E., Song C., Ye K., Sun D., Ferrazzano P., Cengiz P. TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender-dependent neuroprotection in mice after perinatal hypoxia and ischemia. CNS Neurol. Disord. Drug Targets. 2013; 12 (3): 360-370. DOI: 10.2174/18715273113129990061. PMID: 23469848
73. Kojima D., Nakamura T., Banno M., Umemoto Y., Kinoshita T., Ishida Y., Tajima F. Head-out immersion in hot water increases serum BDNF in healthy males. Int. J. Hyperthermia. 2018; 34 (6): 834-839. DOI: 10.1080/02656736.2017.1394502. PMID: 29157042
74. Ostrowski R.P., Graupner G., Titova E., Zhang J., Chiu J., Dach N., Corleone D., Tang J., Zhang J.H. The hyperbaric oxygen preconditioning-induced brain is mediated by a reduction of early apoptosis after transient cerebral ischemia. Neurobiol. Dis. 2008; 29 (1): 1–13. DOI: 10.1016/j.nbd. 2007.07.020. PMID: 17822911
75. Chen X., Wang K. The fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995-2015. Acta Pharm. Sin. B. 2016; 6 (6): 522-530. DOI: 10.1016/j.apsb.2016.06.013. PMID: 27818918
76. Zhao H., Alam A., San C.Y., Eguchi S., Chen Q., Lian Q., Ma D. Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: recent developments. Brain Res. 2017; 1665: 1-21. DOI: 10.1016/j.brainres.2017.03.029. PMID: 28396009
77. Wang J., Zhang S., Ma H., Yang S., Liu Z., Wu X., Wang S., Zhang Y., Liu Y. Chronic intermittent hypobaric hypoxia pretreatment ameliorates ischemia-induced cognitive dysfunction through activation of ERK1/2-CREB-BDNF pathway in anesthetized mice. Neurochem. Res. 2017; 42 (2): 501-512. DOI: 10.1007/s11064-016-2097-4. PMID: 27822668
78. Narantuya D., Nagai A., Sheikh A.M., Masuda J., Kobayashi S., Yamaguchi S., Kim S.U. Human microglia transplanted in rat focal ischemia brain induce neuroprotection and behavioral improvement. PLoS One. 2010; 5 (7): e11746. DOI: 10.1371/journal.pone.0011746. PMID: 20668522
79. Ishrat T., Sayeed I., Atif F., Hua F., Stein D.G. Progesterone is neuroprotective against ischemic brain injury through its effects on the PI3K/Akt signaling pathway Neuroscience. 2012; 210: 442–450. DOI: 10.1016/ j.neuroscience.2012.03.008. PMID: 22450229
80. Singh M., Su C. Progesterone-induced neuroprotection: factors that may predict therapeutic efficacy. Brain Res. 2013; 1514: 98-106. DOI: 10.1016/j.brainres.2013.01.027. PMID: 23340161
81. Taliyan R., Ramagiri S. Delayed neuroprotection against cerebral ischemia reperfusion injury: putative role of BDNF and GSK-3 . J. Recept Signal Transduct. Res. 2016; 36 (4): 402-410. DOI: 10.3109/ 10799893.2015.1108338. PMID: 26554621
82. Sangiovanni E., Brivio P., Dell’Agli M., Calabrese F. Botanicals as modulators of neuroplasticity: focus on BDNF. Neural. Plast. 2017; 2017: 5965371. DOI: 10.1155/2017/5965371. PMID: 29464125
83. Wei H., Sun T., Tian Y., Wang K. Ginkgolide B modulates BDNF expression in acute ischemic stroke. J. Korean Neurosurg. Soc. 2017; 60 (4): 391-396. DOI: 10.3340/jkns.2016.1010.018. PMID: 28689387
84. Park C.H., Kwak Y.S. Analysis of energy restriction and physical activity on brain function: the role of ketone body and brain-derived neurotrophic factor. J. Exerc. Rehabil. 2017; 13 (4): 378-380. DOI: 10.12965/ jer.1735028.514. PMID: 29114500
85. Shin M.K., Kim H.G., Kim K.L. A novel brain-derived neurotrophic factor-modulating peptide attenuates A 1-42-induced neurotoxicity in vitro. Neurosci. Lett. 2015; 595: 63-68. DOI: 10.1016/ j.neulet.2015.03.070. PMID: 25849526
86. Zhang Y., Lan R., Wang J., Li X.Y., Zhu D.N., Ma Y.Z., Wu J.T., Liu Z.H. Acupuncture reduced apoptosis and up-regulated BDNF and GDNF expression in hippocampus following hypoxia–ischemia in neonatal rats. J. Ethnopharmacol. 2015; 172: 124-132. DOI: 10.1016/j.jep.2015.06.032. PMID: 26116163
87. Fahimi A., Baktir M.A., Moghadam S., Mojabi F.S., Sumanth K., McNerney M.W., Ponnusamy R., Salehi A. Physical exercise induces structural alterations in the hippo1campal astrocytes: exploring the role of BDNFTrkB signaling. Brain Struct. Funct. 2017; 222 (4): 1797-1808. DOI: 10.1007/s00429-016-1308-8. PMID: 27686571
88. Jeon Y.K., Ha C.H. The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents. Environ. Health Prev. Med. 2017; 22 (1): 27. DOI: 10.1186/s12199-017-0643-6. PMID: 29165142
89. Coelho F.G., Gobbi S., Andreatto C.A., Corazza D.I., Pedroso R.V., Santos-Galduróz R.F. Physical exercise modulates peripheral levels of brain-de-rived neurotrophic factor (BDNF): a systematic review of experimental studies in the elderly. Arch. Gerontol. Geriatr. 2013; 56 (1): 10-15. DOI: 10.1016/j.archger.2012.06.003. PMID: 22749404
90. Luo J., Zheng H., Zhang L., Zhang Q., Li L., Pei Zh., Hu X. High-frequency repetitive transcranial magnetic stimulation (rTMS) improves functional recovery by enhancing neurogenesis and activating BDNF/TrkB signaling in ischemic rats. Int. J. Mol. Sci. 2017; 18 (2): pii: E455. DOI: 10.3390/ijms18020455. PMID: 28230741
91. Bucur M., Papagno C. A systematic review of noninvasive brain stimulation for post-stroke depression. J. Affect. Disord. 2018; 238: 69-78. DOI: 10.1016/j.jad.2018.05.026. PMID: 29860185
92. Yozbatiran N., Alonso-Alonso M., See J., Demirtas-Tatlidede A., Luu D., Motiwala R.R., Pascual-Leone A., Cramer S.C. Safety and behavioral effects of high-frequency repetitive transcranial magnetic stimulation in stroke. Stroke. 2009; 40: 309–312. DOI: 10.1161/STROKEAHA. 108.522144. PMID: 18845801
93. Patz S., Wahle P. Neurotrophins induce short-term and long-term changes of cortical neurotrophin expression. Eur. J. Neurosci. 2004; 20 (3): 701-708. DOI: 10.1111/j.1460-9568.2004.03519.x. PMID: 15255980
94. Kuo L.T., Groves M.J., Scaravilli F., Sugden D., An S.F. Neurotrophin-3 administration alters neurotrophin, neurotrophin receptor and nestin mRNA expression in rat dorsal root ganglia following axotomy. Neuroscience. 2007; 147 (2): 491-507. DOI: 10.1016/j.neuroscience.2007. 04.023. PMID: 17532148
95. Rosso P., De Nicolò S., Carito V., Fiore M., Iannitelli A., Moreno S., Tirassa P. Ocular nerve growth factor administration modulates brain-derived neurotrophic factor signaling in prefrontal cortex of healthy and diabetic rats. CNS Neurosci. Ther. 2017; 23 (3): 198-208. DOI: 10.1111/cns.12661. DOI: 10.1111/cns.12661. PMID: 28044424
96. Kiprianova I., Schindowski K., Bohlen und Halbach O., Krause S., Dono R., Schwaninger M., Unsicker K. Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2. Exp. Neurol. 2004; 189 (2): 252-260. DOI: 10.1016/j.expneurol. 2004.06.004. PMID: 15380477
97. Аврущенко М.Ш., Острова И.В., Заржецкий Ю.В., Мороз В.В., Гудашева Т.А., Середенин С.Б. Влияние миметика фактора роста нервов ГК-2 на постреанимационную экспрессию нейротрофических факторов. Патол. физиол. и эксперим. терапия. 2015; 59 (2): 12-18. PMID: 26571801
98. Gudasheva T.A., Povarnina P.Yu., Antipova T.A., Seredenin S.B. A novel dimeric dipeptide mimetic of the nerve growth factor exhibits pharmacological effects upon systemic administration and has no side effects accompanying the neurotrophin treatment. Neurosci. Med. 2014; 5 (2): 101-108. DOI: 10.4236/nm.2014.52013
99. Alyautdin R., Khalin I., Nafeeza M.I., Haron M.H., Kuznetsov D. Nanoscale drug delivery systems and the blood-brain barrier. Int. J. Nanomedicine. 2014; 9: 795-811. DOI: 10.2147/IJN.S52236. PMID: 24550672
100. Shi Q., Zhang P., Zhang J., Chen X., Lu H., Tian Y., Parker T.L., Liu Y. Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice. Neurosci. Lett. 2009; 465 (3): 220-225. DOI: 10.1016/j.neulet.2009.08.049. PMID: 19703519
101. Zhang Y., Pardridge W.M. Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion. Brain Res. 2006; 1111 (1): 227-229. DOI: 10.1016/j.brainres.2006.07.005. PMID: 16884698
102. Shirakura M., Inoue M., Fujikawa S., Washizawa K., Komaba S., Maeda M., Watabe K., Yoshikawa Y., Hasegawa M. Postischemic administration of Sendai virus vector carrying neurotrophic factor genes prevents delayed neuronal death in gerbils. Gene Ther. 2004; 11 (9): 784–790. DOI: 10.1038/sj.gt.3302224. PMID: 14961067
103. Zhu J.M., Zhao Y.Y., Chen S.D., Zhang W.H., Lou L., Jin X. Functional recovery after transplantation of neural stem cells modified by brain-derived neurotrophic factor in rats with cerebral ischemia. J. Int. Med. Res. 2011; 39 (2): 488–498. DOI: 10.1177/147323001103900216. PMID: 21672352
104. Kurozumi K., Nakamura K., Tamiya T., Kawano Y., Ishii K., Kobune M., Hirai S., Uchida H., Sasaki K., Ito Y., Kato K., Honmou O., Houkin K., Date I., Hamada H. Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Mol. Ther. 2005; 11 (1): 96-104. DOI: 10.1016/j.ymthe.2004. 09.020. PMID: 15585410
105. Jeong C.H., Kim S.M., Lim J.Y., Ryu C.H., Jun J.A., Jeun S.S. Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model. Biomed. Res. Int. 2014; 2014: 129145. DOI: 10.1155/2014/129145. PMID: 24672780
106. Harris N.M., Ritzel R., Mancini N., Jiang Y., Yi X., ManickamD.S., Banks W. A., Kabanov A.V., McCullough L.D., Verma R. Nano-particle delivery of brain derived neurotrophic factor after focal cerebral ischemia reduces tissue injury and enhances behavioral recovery. Pharmacol. Biochem. Behav. 2016; 150-151: 48–56. DOI: 10.1016/j.pbb.2016.09.003. PMID: 27619636
107. Boado R.J., Pardridge W.M. The Trojan horse liposome technology for nonviral gene transfer across the blood-brain barrier. J. Drug Deliv. 2011; 2011: 296151. DOI: 10.1155/2011/296151. PMID: 22175028
108. Ghosh B., Wang Z., Nong J., Urban M.W., Zhang Z., Trovillion V.A., Wright M.C., Zhong Y., Lepore A.C. Local BDNF delivery to the injured cervical spinal cord using an engineered hydrogel enhances diaphragmatic respiratory function. J. Neurosci. 2018; 38 (26): 5982-5995. DOI: 10.1523/JNEUROSCI.3084-17.2018. PMID: 29891731
Для цитирования:
Острова И.В., Голубева Н.В., Кузовлев А.Н., Голубев А.М. Прогностическая значимость и терапевтический потенциал мозгового нейротрофическго фактора BDNF при повреждении головного мозга (обзор). Общая реаниматология. 2019;15(1):70-86. https://doi.org/10.15360/1813-9779-2019-1-70-86
For citation:
Ostrova I.V., Golubeva N.V., Kuzovlev A.N., Golubev A.M. Prognostic Value and Therapeutic Potential of Brain-Derived Neurotrophic Factor (BDNF) in Brain Injuries (Review). General Reanimatology. 2019;15(1):70-86. (In Russ.) https://doi.org/10.15360/1813-9779-2019-1-70-86
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