Прогностическая значимость и терапевтический потенциал мозгового нейротрофическго фактора BDNF при повреждении головного мозга (обзор)
Аннотация
Нейротрофины — это белки, играющие важную роль в функционировании нервной системы, регулируя клеточную пролиферацию, дифференцировку, процессы выживания и гибели нейронов, участвуя в механизмах нейрональной пластичности. Мозговой нейротрофический фактор (Brain-Derived Neurotrophic Factor — BDNF) — один из наиболее охарактеризованных представителей семейства нейротрофинов, которому в последние годы уделяется пристальное внимание. Его считают одним из ключевых медиаторов выживания и восстановления нейронов, а снижение содержания BDNF является общим механизмом, лежащим в основе развития различных нейродегенеративных заболеваний. В обзоре рассмотрены изменения содержания BDNF при повреждении мозга, вызванном ишемией и травмой, перспективы его использования в клинике в качестве маркера нарушения функций мозга, а также возможности его применения для лечения постишемических энцефалопатий.
Ключевые слова
Об авторах
И. В. Острова
НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР
Россия
Россия
Н. В. Голубева
НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР
Россия
Россия
А. Н. Кузовлев
НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР
Россия
Россия
А. М. Голубев
НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР;
Российский университет дружбы народов
Россия
Россия
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Для цитирования:
Острова И.В., Голубева Н.В., Кузовлев А.Н., Голубев А.М. Прогностическая значимость и терапевтический потенциал мозгового нейротрофическго фактора BDNF при повреждении головного мозга (обзор). Общая реаниматология. 2019;15(1):70-86. https://doi.org/10.15360/1813-9779-2019-1-70-86
For citation:
Ostrova I.V., Golubeva N.V., Kuzovlev A.N., Golubev A.M. Prognostic Value and Therapeutic Potential of Brain-Derived Neurotrophic Factor (BDNF) in Brain Injuries (Review). General Reanimatology. 2019;15(1):70-86. (In Russ.) https://doi.org/10.15360/1813-9779-2019-1-70-86
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