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Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation

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Thrombolytic treatment during cardiopulmonary resuscitation is thought to reverse the cerebral no-reflow phenomenon which is widely considered to limit neurological recovery after prolonged cardio-circulatory arrest. However, the recent multicenter randomized double-blind TROICA (Thrombolysis in Cardiac Arrest) trial revealed that patients with witnessed out-of-hospital cardiac arrest did not experience an improvement of neurological outcome when treated with the thrombolytic agent tenecteplase [1]. This raises the question of the importance of coagulation disturbances in the pathophysiology of no-reflow and its reversal by thrombolytic interventions. This article provides an overview of the experimental literature on this subject. 

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Для цитирования:

Hossmann K.-., Hossmann V., Bottiger B.W. Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation. Общая реаниматология. 2009;5(2):31.

For citation:

Hossmann K.-., Hossmann V., Bottiger B.W. Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation. General Reanimatology. 2009;5(2):31.

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