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Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation

https://doi.org/10.15360/1813-9779-2009-2-31

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Аннотация

Thrombolytic treatment during cardiopulmonary resuscitation is thought to reverse the cerebral no-reflow phenomenon which is widely considered to limit neurological recovery after prolonged cardio-circulatory arrest. However, the recent multicenter randomized double-blind TROICA (Thrombolysis in Cardiac Arrest) trial revealed that patients with witnessed out-of-hospital cardiac arrest did not experience an improvement of neurological outcome when treated with the thrombolytic agent tenecteplase [1]. This raises the question of the importance of coagulation disturbances in the pathophysiology of no-reflow and its reversal by thrombolytic interventions. This article provides an overview of the experimental literature on this subject. 

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Для цитирования:


Hossmann K.-., Hossmann V., Bottiger B.W. Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation. Общая реаниматология. 2009;5(2):31. https://doi.org/10.15360/1813-9779-2009-2-31

For citation:


Hossmann K.-., Hossmann V., Bottiger B.W. Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation. General Reanimatology. 2009;5(2):31. https://doi.org/10.15360/1813-9779-2009-2-31

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ISSN 1813-9779 (Print)
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