Preview

Общая реаниматология

Расширенный поиск

Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation

https://doi.org/10.15360/1813-9779-2009-2-31

Аннотация

Thrombolytic treatment during cardiopulmonary resuscitation is thought to reverse the cerebral no-reflow phenomenon which is widely considered to limit neurological recovery after prolonged cardio-circulatory arrest. However, the recent multicenter randomized double-blind TROICA (Thrombolysis in Cardiac Arrest) trial revealed that patients with witnessed out-of-hospital cardiac arrest did not experience an improvement of neurological outcome when treated with the thrombolytic agent tenecteplase [1]. This raises the question of the importance of coagulation disturbances in the pathophysiology of no-reflow and its reversal by thrombolytic interventions. This article provides an overview of the experimental literature on this subject. 

Список литературы

1. Bottiger B.W., Arntz H., Chamberlain D. et al.

2. Bottiger B.W.Thrombolysis during cardiopulmonary resuscitation. Fibrinolysis & Proteolysis 1997; 11: 93—100.

3. Newman D., Greenwald I., Callaway C.Cardiac arrest and the role of thrombolytic agents. Ann. Emerg. Med. 2000; 35 (5): 472—480.

4. Bottiger B. W., MotschJ., Bohrer H. et al.Activation of blood coagulation after cardiac arrest is not balanced adequately by activation of endogenous fibrinolysis. Circulation 1995; 92 (9): 2572—2578.

5. Hossmann K.-A.Reperfusion of the brain after global ischemia: hemo-dynamic disturbances. Shock 1997; 8 (2): 95—101; discussion 102—103.

6. Aliyev F., Habeb M., Babalik E. et al.Thrombolysis with streptokinase during cardiopulmonary resuscitation: A single center experience and review of the literature. J. Thromb. Thrombolysis 2005; 20 (3): 169—173.

7. Bozeman W. P., Kleiner D. M., Ferguson K. L.Empiric tenecteplase is associated with increased return of spontaneous circulation and short term survival in cardiac arrest patients unresponsive to standard interventions. Resuscitation 2006; 69 (3): 399—406.

8. Lederer W., Lichtenberger C., Pechlaner C. et al.Long-term survival and neurological outcome of patients who received recombinant tissue plas-minogen activator during out-of-hospital cardiac arrest. Resuscitation 2004; 61 (2): 123—129.

9. Bottiger B. W., Bode C., Kern S. et al.Efficacy and safety of thrombolyt-ic therapy after initially unsuccessful cardiopulmonary resuscitation: a perspective clinical trial. Lancet 2001; 357 (9268): 1583—1585.

10. Soltesz S., Berg K., Molter G.Successful thrombolysis of a severe pulmonary embolism during cardiopulmonary resuscitation. Anaesthesist 1997; 46 (10): 890—894.

11. Kuisma M., Silfvast T., Voipio V., Malmstrom R.Prehospital thrombolyt-ic treatment of massive pulmonary embolism with reteplase during car-diopulmonary resuscitation. Resuscitation 1998; 38 (1): 47—50.

12. Schulte-Sinkus D., Standl T.Successful resuscitation after bolus injection of tissue-type plasminogen activator in emergency admission. Anasthesiol. Intensivmed. Notfallmed. Schmerzther 1998; 33 (2): 124—128.

13. Grabner C., Wahl U., Reineke H.Successful cardiopulmonary resuscitation with a high-dosage bolus injection of rt-PA after fulminant pulmonary embolism. Anasthesiol. Intensivmed. Notfallmed. Schmerzther 2001; 36 (5): 306—308.

14. Schreiber W., Gabriel D., Sterz F. et al.Thrombolytic therapy after cardiac arrest and its effect on neurological outcome. Resuscitation 2002; 52 (1): 63—69.

15. Li X., Fu Q. L., JingX. L. et al.A meta-analysis of cardiopulmonary resuscitation with and without the administration of thrombolytic agents. Resuscitation 2006; 70 (1): 31—36.

16. Fatovich D., Dobb G., Clugston R.A pilot randomised trial of thrombolysis in cardiac arrest (The TICA trial). Resuscitation 2004; 61 (3): 309—313.

17. Padosch S. A., Motsch J., Bottiger B. W.Thrombolysis during cardiopul-monary resuscitation. Anaesthesist 2002; 51 (7): 516—532.

18. Kurkciyan I., Meron G., Sterz F. et al.Pulmonary embolism as cause of cardiac arrest: presentation and outcome. Arch. Intern. Med. 2000; 160 (10): 1529—1535.

19. Gramann J., Lange-Braun P., Bodemann T. et al.Der Einsatz von Thrombolytika in der Reanimation als Ultima ratio zur Uberwindung des Herztodes. Intensiv und Notfallbehandlung 1991; 16: 134—137.

20. Kleiner D., Ferguson K., King K. et al.Empiric tenecteplase use in cardiac arrest refractory to standard advanced cardiac life support interventions. Circulation 2003; 108: 318—319.

21. Lederer W., Lichtenberger C., Pechlaner C. et al.Recombinant tissue plasminogen activator during cardiopulmonary resuscitation in 108 patients with out-of-hospital cardiac arrest. Resuscitation 2001; 50 (1): 71—76.

22. Spohr F., Bottiger B.W.Safety of thrombolysis during cardiopulmonary resuscitation. Drug Saf. 2003; 26 (6): 367—379.

23. Abu-Laban R. B., Christenson J. M., Innes G. D.Effects of thrombolysis during out-of-hospital cardiopulmonary resuscitation. Am. J. Cardiol. 2006; 98 (3): 426—427.

24. Stadlbauer K. H., Krismer A. C., Arntz H. R. et al.Effects of thrombolysis during out-of-hospital cardiopulmonary resuscitation. Am. J. Cardiol. 2006; 97 (3): 305—308.

25. Konstantinides S., Geibel A., Heusel G. et al.Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. N. Engl. J. Med. 2002; 347 (15): 1143—1150.

26. Spohr F., Arntz H. R., Bluhmki E. et al.International multicentre trial protocol to assess the efficacy and safety of tenecteplase during car-diopulmonary resuscitation in patients with out-of-hospital cardiac arrest: The Thrombolysis in Cardiac Arrest (TROICA) Study. Eur. J.

27. Clin. Invest. 2005; 35 (5): 315—323.

28. Ames A., Wright R. L., Kowada M. et al.Cerebral ischemia II. The no-reflow phenomenon. Am. J. Pathol. 1968; 52 (2): 437—453.

29. Ames A., Gurian B.Effects of glucose and oxygen deprivation on function of isolated mammalian retina. J. Neurophysiol. 1963; 26: 617—634.

30. Hirsch H., Euler K., Schneider M.Uber die Erholung und Wiederbelebung des Gehirns nach Ischumie bei Normothermie. PflUgers Arch. Eur. J. Physiol. 1957; 265 (4): 281—313.

31. Rezkalla S., Kloner R.No-reflow phenomenon. Circulation 2002; 105 (5): 656—662.

32. Fischer E. G., Ames A.Studies on mechanisms of impairment of cerebral circulation following ischemia: effect of hemodilution and perfusion pressure. Stroke 1972; 3 (5): 538—542.

33. Fischer M., Hossmann K.-A.No-reflow after cardiac arrest. Intensive Care Med. 1995; 21 (2): 132—141.

34. Bottiger B. W., Krumnikl J. J., Gass P. et al.The cerebral no-reflow phenomenon after cardiac arrest in rats-influence of low-flow reperfusion. Resuscitation 1997; 34 (1): 79—87.

35. Hossmann V., Hossmann K.-A.Return of neuronal functions after prolonged cardiac arrest. Brain Res. 1973; 60 (2): 423—438.

36. Safar P., Abramson N. S., Angelos M. et al.Emergency cardiopulmonary bypass for resuscitation from prolonged cardiac arrest. Am. J. Emerg. Med. 1990; 8 (1): 55—67.

37. Iijima T., Bauer R., Hossmann K.-A.Brain resuscitation by extracorpo-real circulation after prolonged cardiac arrest in cats. Intensive Care Med. 1993; 19 (2): 82—88.

38. Seo K., Ishimaru S., Hossmann K.-A.2-stage resuscitation of the cat brain after prolonged cardiac arrest. Intens. Care Med. 1991; 17 (7): 410—418.

39. Hossmann K.-A., Kleihues P.Reversibility of ischemic brain damage. Arch. Neurol. 1973; 29 (6): 375—384.

40. Gando S., Kameue T., Nanzaki S. et al.Massive fibrin formation with consecutive impairment of fibrinolysis in patients with out-of-hospital cardiac arrest. Thromb. Haemost. 1997; 77 (2): 278—282.

41. Gaszynski W.Research work on blood clotting system during car-diorespiratory resuscitation. Anaesth. Resusc. Intens. Ther. 1974; 2 (4): 303—316.

42. Anderson J. M., Brown J. K., Cockburn F.On the role of disseminated intravascular coagulation in the pathology of birth asphyxia. Dev. Med. Child Neurol. 1974; 16 (5): 581—591.

43. Wroblewski M.,Jarzyna A., Obrzut A.The effect of cerebral anoxia on blood coagulation in the guinea-pig. Acta Neurochir. 1966; 15 (3): 263—268.

44. GeraudJ., Rascol A., Bierme R. et al.Troubles de la fonction plaquettaire et accidents ischemiques cerebraux. Perspectives therapeutiques. Rev. Neurol. 1972; 126 (1): 31—40.

45. Hossmann K.-A., Hossmann V.Coagulopathy following experimental cerebral ischemia. Stroke 1977; 8 (2): 249—254.

46. Lip G. Y., Blann A. D.Thrombogenesis and fibrinolysis in acute coronary syndromes. Important facets of a prothrombotic or hypercoagula-ble state? J. Am. Coll. Cardiol. 2000; 36 (7): 2044—2046.

47. Hossmann V., Hossmann K.-A., Takagi S.Effect of intravascular platelet aggregation on blood recirculation following prolonged ischemia of the cat brain. J. Neurol. 1980; 222 (3): 159—170.

48. CrowellJ., Sharpe G., Lambright R. et al.The mechanism of death after resuscitation following acute circulatory failure. Surgery 1955; 38 (4): 696—702.

49. CrowellJ. W., Smith E. E.Effect of fibrinolytic activation on survival and cerebral damage following periods of circulatory arrest. Am. J. Physiol. 1956; 186 (2): 283—285.

50. Lin S.-R., O ‘Connor M.J., Fischer H. W. et al.The effect of combined dextran and streptokinase on cerebral function and blood flow after cardiac arrest: an experimental study on the dog. Invest. Radiol. 1978; 13 (6): 490—498.

51. Sterz F., Safar P., Tisherman S. et al.Mild hypothermia cardiopulmonary resuscitation improves outcome after prolonged cardiac arrest in dogs. Crit. Care Med. 1991; 19 (3): 379—389.

52. Hartveit F., Halleraker B.Intravascular changes in kidneys and lungs after external cardiac massage: a preliminary report. J. Pathol. 1970; 102 (1): 54—58.

53. Fischer M., Bottiger B. W., Popovcenic S. et al.Thrombolysis using plas-minogen activator and heparin reduces cerebral no-reflow after resuscitation from cardiac arrest — an experimental study in the cat. Intensive Care Med. 1996; 22: 1214—1223.

54. Bottiger B. W., Padosch S. A.Thrombolysis using recombinant tissue-type plasminogen activator during cardiopulmonary resuscitation in patients with out-of- hospital cardiac arrest. Resuscitation 2002; 52 (3): 308—309.

55. Jan K., Powers E., Reinhart W. et al.Altered rheological properties of blood following administrations of tissue plasminogen activator and streptokinase in patients with acute myocardial infarction. Adv. Exp. Med. Biol. 1990; 281: 409—417.


Рецензия

Для цитирования:


Hossmann K.-., Hossmann V., Bottiger B.W. Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation. Общая реаниматология. 2009;5(2):31. https://doi.org/10.15360/1813-9779-2009-2-31

For citation:


Hossmann K.-., Hossmann V., Bottiger B.W. Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation. General Reanimatology. 2009;5(2):31. https://doi.org/10.15360/1813-9779-2009-2-31

Просмотров: 1039


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1813-9779 (Print)
ISSN 2411-7110 (Online)