Role of Leptin in the Pathogenesis of Reproductive Disorders in Adolescent Girls with Anorexia Nervosa
https://doi.org/10.15360/1813-9779-2007-4-98-101
Abstract
Objective: to study a role of leptin in the pathogenesis of reproductive disorders in adolescent girls with anorexia nervosa (AN).
Subjects: Two groups of patients the common symptoms of whom were underweight, amenorrhea, the absence of chromosomal or monogenic abnormality. Group 1 consisted of 48 adolescent girls diagnosed as having anorexia nervosa; Group 2 included 41 patients without eating behavioral disorders. A control group comprised 24 patients with a body mass index (BMI) of 20.3 (18.5; 24.9) without eating behavioral disorders and with a normal menstrual cycle. Methods: anthropometry, enzyme immunoassay of plasma leptin and neuropeptide Y levels. The statistical validity of group differences was estimated by the Mann-Whitney U-test.
Results. There were reductions in the serum content of leptin in patients at an anorectic stage, its hyperproduction at the stage of AN reduction, and no relationship of the leptin concentration to BMI. Hypoleptinemia at the anorectic stage was accompanied by low neuropeptide Y levels. This suggests that resistance to low leptin levels develops, which may be caused by both impaired leptin transport across the blood-brain barrier and hypoinsulinemia.
Conclusion. The low levels of leptin and neuropeptide Y at the anorectic stage may be considered to be an adaptive reaction that delays insulin effects in the presence of malnutrition and creates a vicious circle in the regulation of the lipostat system and vicious circle-associated reproductive disorders.
About the Author
V. O. Andreyeva
Rostov Research Institute of Obstetrics and Pediatrics, Rostov-on-Don
References
1. Международная классификация болезней (10-й пересмотр). Психические расстройства и расстройства поведения. М.: Минздрав России; 1998.
2. Гоготадзе И. Н., Самохвалов В. Е. Нервная анорексия. СПб.: ГПМА; 2002.
3. Богданова Е. А. Гинекология детей и подростков. М.: МИА; 2000.
4. Escobar L., Freire J. M., Giron J. A. et al. Plasma levels of insulin and leptin in patients with morbid obesity and anorexia nervosa after weight loss or gain, respectively. Rev. Esp. Med. Nucl., 2000; 19:199—206.
5. Мельниченко Г. А., Романцова Т. И. Ожирение: эпидемиология, классификация, патогенез, клиническая симптоматика и диагностика. В кн.: Дедов И. И., Мельниченко Г. А. (ред.) Ожирение. Этиология, патогенез, клинические аспекты: Руководство для врачей. М.: МИА; 2004. 16—42.
6. Зайчик А. Ш., Чурилов Л. П. Основы патохимии. СПб.: ЭЛБИ; 2000.
7. Miller K. K., Parulekar M. S., Schoenfeld E. et al. Decreased leptin levels in normal weight women with hypothalamic amenorrhea: The effects of body composition and nutritional intake. J. Сlin. Еndocr. Metabolism 1998; 83 (7): 2309—2312.
8. Mayer L., Walsh B. T., Pierson R. N. et al. Body fat redistribution after weight gain in women with anorexia nervosa. Am. J. Clin. Nutr. 2005; 81 (6): 1286—1291.
9. Mantzoroz C. S. Role of leptin in reproduction. In: Ann. N. Y. Acad. Sci. 2000; 900. 174—83.
10. Frieling H., Wilhelm J., Fiszer R. et al. Homocysteine plasma levels are elevated in females with anorexia nervosa. J. Neural. Transm. 2005; 112 (7): 979—985.
11. Gorman R., Funanage M. L, Spear S. G., Hassink K. et al. Immaturity or Starvation? Longitudinal study of leptin levels in premature infants. J. Biology neonate 2001; 80 (1): 35—40.
Review
For citations:
Andreyeva V.O. Role of Leptin in the Pathogenesis of Reproductive Disorders in Adolescent Girls with Anorexia Nervosa. General Reanimatology. 2007;3(4):98-101. (In Russ.) https://doi.org/10.15360/1813-9779-2007-4-98-101
Views:
1220
Email this article 